sexta-feira, 23 de maio de 2008

Diabetes e Sindrome Metabólica

Na edição do The Lancet dessa semana, http://www.thelancet.com para quem se inscrever e, com acesso livre para assinantes do Science Direct vários artigos de folego sobre diabetes e a tal da síndrome metabólica.Vale o passeio nesse final de feriado.
Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies Background: Clinical use of criteria for metabolic syndrome to simultaneously predict risk of cardiovascular disease and diabetes remains uncertain. We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations. Methods We related metabolic syndrome (defined on the basis of criteria from the Third Report of the National Cholesterol Education Program) and its five individual components to the risk of events of incident cardiovascular disease and type 2 diabetes in 4812 non-diabetic individuals aged 70–82 years from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). We corroborated these data in a second prospective study (the British Regional Heart Study [BRHS]) of 2737 non-diabetic men aged 60–79 years. Findings :In PROSPER, 772 cases of incident cardiovascular disease and 287 of diabetes occurred over 3·2 years. Metabolic syndrome was not associated with increased risk of cardiovascular disease in those without baseline disease (hazard ratio 1·07 [95% CI 0·86–1·32]) but was associated with increased risk of diabetes (4·41 [3·33–5·84]) as was each of its components, particularly fasting glucose (18·4 [13·9–24·5]). Results were similar in participants with existing cardiovascular disease. In BRHS, 440 cases of incident cardiovascular disease and 105 of diabetes occurred over 7 years. Metabolic syndrome was modestly associated with incident cardiovascular disease (relative risk 1·27 [1·04–1·56]) despite strong association with diabetes (7·47 [4·90–11·46]). In both studies, body-mass index or waist circumference, triglyceride, and glucose cutoff points were not associated with risk of cardiovascular disease, but all five components were associated with risk of new-onset diabetes. Interpretation: Metabolic syndrome and its components are associated with type 2 diabetes but have weak or no association with vascular risk in elderly populations, suggesting that attempts to define criteria that simultaneously predict risk for both cardiovascular disease and diabetes are unhelpful. Clinical focus should remain on establishing optimum risk algorithms for each disease

Um comentário:

Ricardo Carvalho disse...

Síndroma metabólico (SM) e diabetes tipo 2 (DT2), não serão faces de uma mesma moeda? E SM, será sintoma ou causa? Síndroma é uma doença com causa desconhecida, será assim? Então porquê o SM não se designa antes doença metabólica, porque suas causas são bem identificáveis: probre controlo glicémico / insulínico, TG altos, HDL baixo, hipertensão, etc. Razões concorrentes: vida moderna, sedentarismo, obesidade, dietas high-carb e low-fat, civiização, etc.